Investigation of the inhibition effect of pitaya (hylocereus guatemalensis) bark extracts on some metabolic enzymes

Pitaya is a tropical and subtropical plant with various uses. In this study, the maceration method obtained acetone, ethanol, ethyl acetate, dichloromethane, methanol from bark parts of pitaya fruit. The in vitro effects fruit peel extracts on critical metabolic enzyme activities acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase (hCA I hCA II), α-glycosidase, were investigated. ethanol (PBE) (IC50: 20.16±0.22 µg/mL, r2:0.9694) for AChE acetone (PBA) (IC50:42.10±1.045 r2:0.9807) extract BChE showed most potent inhibition effect. acetate (PBEA) inhibitory effect II (IC50:53.51±2.22 r2:0.9562 IC50:26.29±0.34 r2:0.9966), respectively. addition, PBEA α-glycosidase 24.54±1.80 r2:0.9199). According to results, can be effectively used treatment diseases such as glaucoma, epilepsy, type 2 Diabetes mellitus (T2DM), Alzheimer's disease (AD).